About GarCitrin®

Introduction:

GarCitrin® is a standardized extract obtained from the dried fruit rinds of Garcinia cambogia and it is standardized for minimum 50% (-) Hydroxycitric acid and minimum 5% Garcinol.

Chemistry of GarCitrin®:

GarCitrin®contains (-)HCA and Garcinol.

Hydroxycitric AcidGarcino

               (-) Hydroxycitric acid                          Garcinol



Pharmacology of HCA - the key active ingredient of Citrin® range of products

The fat regulating mechanism of Hydroxycitrate (HCA) was uncovered when scientists were scrutinizing different steps of Krebs cycle.

Biosynthesis of fatty acids takes place naturally in the Krebs Cycle by the following mechanism.

  • Glycolysis breaks the glucose into pyruvate.

  • Pyruvate decarboxylates to give Acetyl CoA in mitochondria.

  • Oxaloacetate combines with Acetyl CoA to form Citrate in the mitochondria.

  • Citrate moves into Cytoplasm and is converted to Acetyl CoA with help of citrate lyase.

  • Acetyl CoA is converted to Malonyl CoA and further it forms Fatty Acids.

Hydroxycitrate (HCA) competes with Citrate to produce outcomes that offer significant benefit in weight management.



1. HCA promotes inhibition of fat synthesis

HCA inhibit enzyme Citrate lyase involved in synthesis of malonyl CoA, a precursor for fatty acid synthesis.




2. HCA promotes fat oxidation:

  • HCA has 100 times greater affinity for Citrate Lyase, hence it acts as a potent inhibitor of Citrate Lyase.

  • Because of its inhibition, very little Acetyl CoA reaches cytoplasm.

  • This in turn limits the activity of Malonyl CoA.

  • Lower levels of Malonyl CoA activates L-carnitine transferase

  • Fatty acids are transported into mitochondria by linking it with L-carnitine. This linking is facilitated by L-carnitine transferase.

  • Hence the oxidation of fatty acids is stimulated.

  • Ability of HCA to promote fat loss in humans result primarily from stimulation of fat oxidation.




3. Suppression of Appetite by HCA:

HCA provides a sense of satiety to the user and this has been clinically found in our various Citrin® trials. Increase in fat metabolism by HCA in liver stimulates gluconeogenesis-glycogen storage in liver. High level of glycogen is signaled by CNS as a state of satiety and a decreased food intake.

  • The activation of fat oxidation by Hydroxycitrate in liver also tends to stimulate gluconeogensis.

  • Pyruvate carboxylase initiate a chain of reactions that converts pyruvate into Glucose.

  • This replenishes the stored Glycogen storage in liver.

  • The high level of Glycogen, as a result of high glucose supply is translated by CNS as a state of satiety.


Amplibio Effect of GarCitrin®:

Amplibio refers to a mechanism wherein either one of the compounds serves to facilitate the biological effect of other compounds or as a result, both biological activities are enhanced.

It was hypothesized that composition comprising HCA in combination with garcinol would be more absorbable and bioavailable to the body and to the individual cells than HCA administered alone resulting in higher rate of the competitive inhibition of ATP citrate lyase and more efficient use as a weight-loss therapy.

The Amplibio action of the HCA/garcinol combination would work hypothetically by the anti-oxidant action neutralizing negative charges surrounding the cell to facilitate transport and uptake of HCA into the cell, by affecting fluidity of cell membranes to facilitate transport and uptake of HCA into the cell, and by synergy with HCA to inhibit citrate lyase, thus lowering the threshold for such inhibition with the HCA.