Clinical Study:

Twelve week, Double Blind, Clinical Comparison of Hydroxycitric Acid (HCA) – Rich Natural Extract and GarCitrin^®.

Study Design:
Patients:	46 overweight healthy women
Dose:	500 mg (HCA, abbreviated as C) tid; 500 mg (GarCitrin®, abbreviated as NC) tid.
Duration:	12 weeks
Conditions:	No change in diet and physical exercise
Clinical evaluation time points:	0, 2,4,6,8,10,12 weeks
Safety parameters:	Physical examination, Pulse rate, Blood pressure.
Efficacy parameters:	Total Body weight, Body composition, Self-assessed appetite and energy levels.

Observation:

During the 12 week trial, the mean values in group NC for body weight and fat content significantly decreased, whereas lean body mass and total body water significantly increased compared to the baseline values and C group values.

Percentage of subjects who experienced weight loss

Percentage of weight loss at consecutive study time intervals

Percentage BMI Change at two study time intervals

Percentage change in Lean Body Mass (LBM) in C Group (Citrin^®) subjects

Percentage change in Lean Body Mass (LBM) in NC Group (GarCitrin^®) subjects

The appetite levels were significantly less in the NC group than the C group, whereas energy levels were equally increased in both study groups as compared to the baseline.

Self assessed appetite levels in the two groups at consecutive study time intervals

No subjective or objective adverse effects were reported in the course of this study. The pulse rate, systolic and diastolic blood pressure were maintained at the same level throughout the study.

In this human double blind clinical trial on GarCitrin^®, it was found to be statistically more effective than HCA in:

• reducing total body weight and body mass index

• reducing body fat

• increasing lean body mass and content of body water

• reducing levels of appetite perception

Also both GarCitrin^® and HCA did not produce subjective or objective side effects.